Category Archives: Media

Research publication: Roles of Interleaflet Coupling and Hydrophobic Mismatch in Lipid Membrane Phase-Separation Kinetics

At last year’s Biophysical Society 2015 meeting, Peter Olmsted and I met Philip Fowler, who at the time worked in Mark Sansom‘s group (he now works in the Nuffield Department of Medicine at Oxford). I had noticed a signal in their lipid bilayer simulations that looked like a two-step asymmetry/symmetry transition we had studied theoretically. Understanding how constituents of a lipid bilayer interact and self-organise is key to the biology of the cell membrane, as well as to applications of synthetic lipid bilayer membranes.

It has been a pleasure to work with Phil and Mark over the past year as we have looked closely into the symmetry and asymmetry of phase-separating bilayers, using a raft (geddit?) of new simulations expertly constructed and analysed by Phil. A joint paper is out now in JACS, linking the kinetics of lipid bilayer phases to a theoretical model of competing inter-leaflet coupling effects. Check it out!

Roles of Interleaflet Coupling and Hydrophobic Mismatch in Lipid Membrane Phase-Separation Kinetics

An achemso.bst LaTeX bibliography style modified to display first page only

I was recently preparing a paper for an ACS journal and had a few issues with the bibliography style. Most of these were fixed by downloading the latest achemso.bst style file from here. However, it didn’t include that the journal seems to use only first pages (not ranges) when making references. That is, an article on pages 1897–1902 is referred to as:

Authors, Journal, Year, Volume, 1897

and not:

Authors, Journal, Year, Volume, 1897–1902.

So, using some information from here I have made a modified achemso.bst that uses only the first page. I don’t know about you but it always takes lot googling to figure out this stuff, so I’ve tried to make this post easily findable by those in a similar situation.

Research publication: Kinetics of symmetry and asymmetry in a phase-separating bilayer membrane

A new paper with Peter Olmsted has just appeared in Physical Review E. Like our recent Soft Matter article, it builds on our theoretical study of coupled lipid bilayer leaflets, investigating the underlying model via direct simulation. We also give a broader look at the use of “leaflet-leaflet” phase diagrams, introduced in previous theoretical works, which allow a more natural interpretation of symmetry and asymmetry in bilayers.

Research publication: Registered/Antiregistered phase separation in bilayers

A couple of days ago, the April 21st 2015 issue of Biophysical Journal came out. My first paper with Peter Olmsted appears within and is featured on the cover! We studied the effects of inter-leaflet coupling in bilayers, and found fascinating kinetics driven by competing stable and metastable phase coexistences, involving registered (symmetric) and antiregistered lipid domains. I won’t go into more detail here, there is a blog post on the Biophysical Society Blog that tells you more.

Cover Image